Yue Zhang; Huadong Luo; Huiyong Ma; Jinqiao Wan; Yue Ji; Alex Shaginian; Jin Li; Yun Deng; Guansai Liu
Bioconjugate Chem., 2021, 32(8), 1576-1580
https://doi.org/10.1021/acs.bioconjchem.1c00346

Abstract

An efficient visible-light-induced alkylation of DNA-tagged quinoxaline-2-ones was described. The methodology demonstrated moderate-to-excellent conversions under mild conditions. The reaction was found to be tolerant with both N-protected α-amino acids and aliphatic carboxylic acids and could be applied to the synthesis of focused DNA-encoded quinoxalin-2-one libraries.