Xiaojie Lu; Sarah Roberts; George Joseph Franklin; Christopher P. Davie
Med. Chem. Commun., 2017, 8, 1614-1617
https://doi.org/10.1039/C7MD00289K

Abstract

Encoded Library Technology (ELT) is a novel hit identification platform synergistic with HTS, Fragment Hit ID and Focused Screening. It provides both an ultra high-throughput and a cost-efficient tool for the discovery of small molecules that bind to protein targets of pharmaceutical interest. The success of ELT relies heavily on the chemical diversity accessed through DNA-Encoded Library (DEL) synthesis. We developed unprecedented on-DNA cross-coupling reactions, including on-DNA Pd and Cu promoted C-N cross-coupling reactions. These reported reactions have strong potential for application in DNA-Encoded Library (DEL) synthesis