Thomas M. Snyder; David R. Liu
Angew. Chem. Int. Ed. Engl., 2005, 44(45), 7379-82
https://doi.org/10.1002/anie.200502879

Abstract

A triolefin and a tripeptide were prepared in a single solution (see scheme) by ordered multistep synthesis. Temperature-sensitive variations in DNA secondary structure were used to orchestrate a series of effective molarity changes among four reactants of comparable intrinsic reactivity, resulting predominantly in one ordered product out of many possibilities. This approach mimics the selective control of effective molarity at precise moments during biosynthesis.