Yiyuan Zhang; Wanting Chen; Tingting Tan; Yuang Gu; Shuning Zhang; Jie Li; Yan Wang; Wei Hou; Guang Yang; Peixiang Ma; Hongtao Xu
Chem. Commun., 2021, 57, 4588-4591
https://doi.org/10.1039/D1CC00769F

Abstract

We report a general palladium-catalyzed one-pot procedure for the synthesis of phosphonates, phosphinates and phosphine oxides from phenols mediated by sulfuryl fluoride. It features mild conditions, broad substrate scope, high functionality tolerance and water insensitive. Its utility has been well demonstrated by gram-scale synthesis, sequential synthesis of click chemistry building blocks, late-stage decoration of drugs and natural products and on-DNA synthesis of phosphine oxide for DNA-encoded library (DEL).