Kunliang Cai; Yuzhao Ran; Wenbo Sun; Sen Gao; Jin Li; Jinqiao Wan; Guansai Liu
Front. Chem., 2022, 10, 851674
https://doi.org/10.3389/fchem.2022.851674

Abstract

C-N bond formation is one of the most commonly used reactions in medicinal chemistry. Herein, we report an efficient Pd-promoted hydroamination reaction between DNA-conjugated aryl alkenes and a wide scope of aliphatic amines. The described reactions are demonstrated in good to excellent conversions to furnish C (sp3)–N bonds on DNA. This DNA-compatible transformation has strong potentials for the application into DNA-encoded library synthesis.