Palladium-Mediated Labeling of Nucleic Acids

Eric Defrancq; Samir Messaoudi
ChemBioChem, 2017, 18, 426-431
https://doi.org/10.1002/cbic.201600599

Abstract

DNA probes: New applications of Pd‐catalyzed coupling reactions for post‐conjugation of nucleic acids have been developed recently. Breakthroughs in this area might now pave the way for the development of sophisticated DNA probes potentially of great interest in chemical biology, nanotechnology, and bioanalysis, as well as in diagnostic domains.
Abstract
New applications of Pd-catalyzed coupling reactions (Suzuki-Miyaura, Sonogashira, and Stille–Migita coupling) for post-conjugation of nucleic acids have been developed recently. Breakthroughs in this area might now pave the way for the development of sophisticated DNA probes, which might be of great interest in chemical biology, nanotechnology, and bioanalysis, as well as in diagnostic domains.

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