Yi Qu; Sixiu Liu; Huanan Wen; Yanfen Xu; Yulong An; Ke Li; Mengyuan Ni; Yanfang Shen; Xiaodong Shi; Wenji Su; Weiren Cui; Letian Kuai; Alexander L. Satz; Hongfang Yang; Xiaojie Lu; Xuanjia Peng
Biochem. Biophys. Res. Commun., 2020, 533, 2, 209-214
https://doi.org/10.1016/j.bbrc.2020.04.027

Abstract

A mild reaction for DNA-compatible, palladium promoted Suzuki-Miyaura cross-coupling reaction of potassium Boc-protected aminomethyltrifluoroborate with DNA-conjugated aryl bromides has been developed efficiently. This novel DNA encoded chemistry reaction proceeded well with a wide range of functional group tolerance, including aryl bromides and heteroaryl bromides. Further, the utility our DNA conjugated aminomethylated arene products is demonstrated by reaction with various types of reagents (including amide formation with carboxylic acids, alkylation with aldehydes, and carbamoylation with amines) as would be desired for the production of a DNA encoded library.