Xuan Wang; Hui Sun; Jiaxiang Liu; Wenge Zhong; Mingqiang Zhang; Hu Zhou; Dongcheng Dai; Xiaojie Lu
Org. Lett., 2019, 21, 3, 719-723
https://doi.org/10.1021/acs.orglett.8b03926

Abstract

Optimal conditions for palladium-promoted Heck reaction on DNA were developed with good to excellent conversions. Versatility with either DNA-conjugated styrene/acrylamide or aryl iodide and a broad substrate scope of the corresponding coupling partners were established. Furthermore, robustness of the Heck reaction conditions on single-strand DNA and feasibility for DNA-encoded library production were demonstrated.