Gang Li; Ying Liu; Yu Liu; Li Chen; Siyu Wu; Yang Liu; Xiaoyu Li
Angew. Chem. Int. Ed. Engl., 2013, 52(36), 9544-9
https://doi.org/10.1002/anie.201302161

Abstract

DNA-templated affinity labeling: Accurate characterization of small-molecule (SM)–protein interactions is one of the most important but also very challenging tasks in chemical biology and drug discovery. A novel method named DNA-programmed photoaffinity labeling is reported. The introduction of DNA encoding and template effect enable multiplexed protein labeling by multiple probes.