Yasaman Mahdavi-Amiri; Molly S. J. Hu; Nicole Frias; Matina Movahedi; Adam Csakai; Lisa A. Marcaurelle; Ryan Hili
Org. Biomol. Chem., 2023, 21(7), 1463-1467
https://doi.org/10.1039/D2OB01956F

Abstract

An efficient approach to the photoredox-catalysed hydroaminoalkylation between on-DNA secondary N-substituted (hetero)arylamines and vinylarenes has been developed and explored. The methodology was examined with a broad scope of vinylarenes and secondary arylamines to establish a preferred building block profile for the process. Compatible substrates furnished the desired derivitised amine products in modest to excellent conversions and with minimal or no detectable by-products.