Matthew E. Welsch; Scott A. Snyder; Brent R. Stockwell
Curr. Opin. Chem. Biol., 2010, 14(3), 347-361
https://doi.org/10.1016/j.cbpa.2010.02.018

Abstract

This review explores the concept of using privileged scaffolds to identify biologically active compounds through building chemical libraries. We hope to accomplish three main objectives: to provide one of the most comprehensive listings of privileged scaffolds; to reveal through four selected examples the present state of the art in privileged scaffold library synthesis (in hopes of inspiring new and even more creative approaches); and also to offer some thoughts on how new privileged scaffolds might be identified and exploited.