Mateja Klika Škopić; Florian Losch; Angus E. McMillan; Niklas Willeke; Mateo Malenica; Luis Bering; Jeffrey Bode; Andreas Brunschweiger
Org. Lett., 2022, 24(6), 1383-1387
https://doi.org/10.1021/acs.orglett.2c00228

Abstract

Reactions that require strictly dry conditions are challenging to translate to a DNA-encoded library format. Controlled pore glass solid support-connected DNA oligonucleotide–aldehyde conjugates could be condensed with SnAP reagents and cyclized to various sp3-rich heterocycles. The Boc-group of products provided a handle for product purification, and its facile removal under acidic conditions was tolerated by a chemically stabilized barcode. The reaction provides reagent-based scaffold diversity with functionalities for further library synthesis.