Lindsay McMurray; Thomas M. McGuire; Rachel L. Howells
Synthesis, 2020, 52(12), 1719-1737
https://doi.org/10.1055/s-0039-1690843

Abstract

This review covers recent advances in decarboxylative photocatalysis applicable to the medicinal chemist. The review is not intended to be exhaustive, but instead is focussed on transformations that could be useful in the synthesis of drug-like compounds in order to highlight the utility of this methodology in the development of new pharmaceutical candidates. 1. Introduction; 2. C–C Bond Formation; 3. C–N and C–O Bond Formation; 4. Fluorination and Trifluoromethylation; 5. Hydrodecarboxylation; 6. Protein Functionalisation; 7. Conclusion