Nari N. Talaty; Robert W. Johnson; James Sawicki; Omprakash Nacham; Stevan W. Djuric
ACS Med. Chem. Lett., 2023, 14(6), 711-718
https://doi.org/10.1021/acsmedchemlett.3c00040

Abstract

The complexity of new therapeutics continues to increase and the timeline for the discovery of these therapeutics continues to shrink. This creates demand for new analytical techniques to facilitate quicker discovery and development of novel drugs. Mass spectrometry is one of the most prolific analytical techniques that has been applied across the entire drug discovery pipeline. New mass spectrometers and the associated methods for sampling have been introduced at a rate that keeps pace with new chemistries, therapeutic types, and screening practices used by modern drug hunters. This microperspective covers application and implementation of new mass spectrometry workflows that enable current and future efforts in screening and synthesis for drug discovery.