Zhennan Fang; Huiqiang Wei; Wenfeng Gou; Leyuan Chen; Changfen Bi; Wenbin Hou; Yiliang Li
Future Med. Chem., 2021, 13(9), 817-837
https://doi.org/10.4155/fmc-2020-0386

Abstract

Nonapoptotic types of regulated cell death have attracted widespread interest since the discovery that certain forms of cell necrosis can be regulated. In particular, research into cell necroptosis has made significant progress in connection with kidney, inflammatory, degenerative and neoplastic diseases. Inhibitors targeting the critical necroptosis-associated proteins RIPK1/3 and MLKL have been in development for more than a decade. Herein the authors compile a list of the known small-molecule inhibitors of these enzymes and representative structures of compounds co-crystallized with these proteins and put forward some thoughts regarding their future development.