Genhong Zhang; Ruoxi Yu; Yuegang Chen
Chin. J. Org. Chem., 2024, 44, XXXX
https://doi.org/10.6023/cjoc202408001

Abstract

Developing economical, efficient, and practical methods to construct C(sp2)-C(sp3) bonds has always been a central issue in synthetic chemistry. In recent years, the use of transition metal-catalyzed C(sp2)-C(sp3) cross coupling has become a powerful synthesis method in photochemical and electrochemical synthesis due to its high functional group compatibility, high reaction selectivity and environmental friendliness. Alcohols, as one of the most widely distributed and naturally abundant organic compounds, has great value in organic chemistry in utilizing alcohol deoxygenation to produce alkyl radicals. In this perspective, we have briefly summaried the C(sp2)-C(sp3) coupling reactions of alcohol derivatives with aryl (pseudo) halides under photo/electro catalysis, including esters, N-heterocyclic carbene adducts, phosphine-oxide adducts, bromides and acetals as alcohol derivatives.