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Nat. Chem., 2018, 10(7), 687
https://doi.org/10.1038/s41557-018-0103-y

Abstract

Encoded chemical libraries can be used to screen a vast array of compounds against a protein target to identify potent binders. A collection of articles in this issue discuss different methods to increase the chemical space sampled by encoded macrocycle libraries and the advantages that such libraries offer for discovering new drug leads.