Screening of a Combinatorial Homing Peptide Library for Selective Cellular Delivery

Nina Svensen; Juan José Díaz‐Mochón; Kevin Dhaliwal; Songsak Planonth; Michael Dewar; J. Douglas Armstrong; Mark Bradley
Angew. Chem. Int. Ed. Engl., 2011, 50, 6133-6136
https://doi.org/10.1002/anie.201101804

Abstract

To the point: The identification of peptides to optimize both the delivery and tumor penetration of existing cancer drugs in a cell‐selective manner would be highly desirable. The screening of a peptide nucleic acid (PNA)‐encoded peptide library (see picture) now allows the identification of versatile cell homing peptides for any cell type of interest.

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