Nicholas Favalli; Gabriele Bassi; Tania Zanetti; Jörg Scheuermann; Dario Neri
Helv. Chim. Acta, 2019, 102, e1900033
https://doi.org/10.1002/hlca.201900033

Abstract

The construction of DNA‐encoded chemical libraries (DECLs) crucially relies on the availability of chemical reactions, which are DNA‐compatible and which exhibit high conversion rates for a large number of diverse substrates. In this work, we present our optimization and validation procedures for three copper and palladium‐catalyzed reactions (Suzuki cross‐coupling, Sonogashira cross‐coupling, and copper(I)‐catalyzed alkyne‐azide cycloaddition (CuAAC)), which have been successfully used by our group for the construction of large encoded libraries.