Markus G. Rudolph
BIOspektrum, 2017, 23, 2, 142-145
https://doi.org/10.1007/s12268-017-0778-4

Abstract

Structure-based drug design requires lead molecules, which traditionally are found by tedious and expensive screening campaigns. By contrast,screening of DNA-encoded small molecule libraries can be much more efficient. Here, the principle and application of the recently developed DNA-encoded library technology (DELT) are discussed.