Francesco Vincenzo Reddavide; Meiying Cui; Weilin Lin; Naiqiang Fu; Stephan Heiden; Helena Andrade; Michael Sion Thompson; Yixin Zhang
Chem. Commun., 2019, 55, 3753-3756
https://doi.org/10.1039/C9CC01429B

Abstract

We present a DNA-encoded chemical library, which allows dynamic selection followed by ligation of the encoding strands. As a chemical approach to mimic the genetic recombination process of adaptive immunity, the technology led to enhanced enrichment factor and signal-to-noise ratio as compared to static libraries.