Matthew A. Clark
Curr. Opin. Chem. Biol., 2010, 14(3), 396-403
https://doi.org/10.1016/j.cbpa.2010.02.017

Abstract

Over the past 10 years, a handful of academic and industrial research groups have developed strategies for the synthesis and interrogation of DNA-encoded small-molecule libraries. These strategies can be divided into those in which DNA directs small-molecule synthesis and those in which it records the synthesis. These libraries have started to yield novel modulators of biological targets, including: SH3-domain-binding peptoids, macrocyclic peptide-based Bcl-XL/BH3 interaction disruptors, ligands for TNF, albumin, streptavidin and others, and small-molecule kinase inhibitors. The DNA-encoded library field holds the potential to address the general problem of biological ligand discovery, including pharmaceutical lead generation.