Mihai Ciobanu; Kuo-Ting Huang; Jean-Pierre Daguer; Sofia Barluenga; Olivier Chaloin; Evelyne Schaeffer; Christopher G. Mueller; Daniel A. Mitchell; Nicolas Winssinger
Chem. Commun., 2011, 47, 9321-9323
https://doi.org/10.1039/C1CC13213J

Abstract

We report the synthesis of a nucleic acid-encoded carbohydrate library, its combinatorial self-assembly into 37,485 pairs and a screen against DC-SIGN leading to the identification of consensus ligand motifs. A prototypical example from the selected pairs was shown to have enhanced binding. A dendrimer incorporating the selected motifs inhibited gp120's binding to dendritic cells with higher efficiency than mannan.