Phillip J. Milnes; Mireya L. McKee; Jonathan Bath; Lijiang Song; Eugen Stulz; Andrew J. Turberfield; Rachel K. O'Reilly
Chem. Commun., 2012, 48, 5614-5616
https://doi.org/10.1039/C2CC31975F

Abstract

Using a strand exchange mechanism we have prepared, by DNA templated chemistry, two 10-mers with defined and tunable monomer sequences. An optimized reaction protocol achieves 85% coupling yield per step, demonstrating that DNA-templated chemistry is a powerful tool for the synthesis of macromolecules with full sequence control.