Fabrice Ndayisenga; Po-Han Lin; Runan Li; Abdul Hameed; Yue Zhang; Kamel Meguellati
Int. J. Biosci., 2020, 16(3), 12-50
http://dx.doi.org/10.12692/ijb/16.3.12-50

Abstract

Functionalization of proteins is a particular domain for the generation of modified proteins constructs which exhibit stimulating and diverse biological properties. The area has enormous potential for chemists and biologists to tune the proteins functions. The site-specific modification of proteins by installing new moieties or subunits provides an excellent opportunity to expand proteins functional abilities. In this review, we highlighted the most significant studies in protein functionalization which include chemical and enzymatic strategies. Exploration of novel methodologies is still on-going and deserves significant attention for future research in protein functionalization.