Yue Zhang; Jia-ying Xue; Xiao-can Su; Wen-jie Xiao; Jing-yi Lv; Wen-xia Shi; Yong Zou; Ming Yan; Xue-jing Zhang
Org. Lett., 2024, XXXX, XXX, XXX-XXX
https://doi.org/10.1021/acs.orglett.4c00377

Abstract

In this report, we present a photopromoted, metal-free transannulation of phenyl azides for the synthesis of DNA-encoded seven-membered rings. The transformation is efficiently achieved through a skeletal editing strategy targeting the benzene motif coupled with a Reversible Adsorption to Solid Support (RASS) strategy. A variety of valuable DNA-encoded seven-membered ring compounds, including DNA-encoded 3H-azepines, azepinones, and unnatural amino acids, are now accessible. Crucially, this DNA-compatible protocol can also be applied for the introduction of complex molecules, as exemplified by Lorcaserin and Betahistine. The selective conversion of readily available phenyl rings into high-value seven-membered rings offers a promising avenue for the construction of diversified and drug-like DNA-encoded library.