Small-molecule diversification from iterated branching reaction pathways enabled by DNA-templated synthesis

Christopher T. Calderone; David R. Liu
Angew. Chem. Int. Ed. Engl., 2005, 44(45),7383-6
https://doi.org/10.1002/anie.200502899

Abstract

Two unique features of DNA-templated synthesis were integrated to prepare complex small molecules by using iterated branching reaction pathways: the direction of multiple, otherwise “incompatible”, reaction types in one reaction vessel and the direction of sequence-programmed subsets of reaction intermediates to appropriate reagents.

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