Nicholas G. Paciaroni; John Maina Ndungu; Thomas Kodadek
Chem. Commun., 2020, 56(34), 4656-4659
https://doi.org/10.1039/D0CC01474E

Abstract

We report chemistry suitable for the solid-phase synthesis of DNA-encoded libraries with an unusually high level of structural diversity. The strategy involves “exploding” an immobilized aldehyde into a plethora of different functional groups under DNA-compatible conditions.