Malliga R. Iyer; Biswajit Kundu; Casey M. Wood
Expert Opin. Ther. Patents, 2022, 32(6), 629-647
https://doi.org/10.1080/13543776.2022.2054329

Abstract

Biological effects mediated by the CYP450 arm of arachidonate cascade implicate the enzyme-soluble epoxide hydrolase (sEH) in hydrolyzing anti-inflammatory epoxy fatty acids to pro-inflammatory diols. Hence, inhibiting the sEH offers a therapeutic approach to treating inflammatory diseases. Over three decades of work has shown the role of sEH inhibitors (sEHis) in treating various disorders in rodents and larger veterinary subjects. Novel chemical strategies to enhance the efficacy of sEHi have now appeared.