Soobin Lee; Hyunchul Kwon; Eun-Kyoung Jee; Jaelim Kim; Kang Ju Lee; Jungyeon Kim; Nakeun Ko; Eunsung Lee; Hyun-Suk Lim
Org. Lett., 2024, XXXX, XXX, XXX-XXX
https://doi.org/10.1021/acs.orglett.3c04387

Abstract

The first synthesis of macrocyclic α-ABpeptoids with varying lengths is described. X-ray crystal structures reveal that cyclic trimer displays a chair-like conformation with a cct amide sequence and cyclic tetramer has a saddle-like structure with an uncommon cccc amide arrangement. The creation of a DNA-encoded combinatorial library of macrocyclic α-ABpeptoids is described.