Synthesis of a PNA-encoded cysteine protease inhibitor library

François Debaene; Lorenzo Mejias; Jennifer L. Harris; Nicolas Winssinger
Tetrahedron, 2004, 60, 8677-8690
https://doi.org/10.1016/j.tet.2004.05.107

Abstract

Peptide nucleic acids (PNAs) have been used to encode a combinatorial library whereby each compound is labeled with a PNA tag which reflects its synthetic history and localizes the compound upon hybridization to an oligonucleotide array. We report herein the full synthetic details for a 4000 member PNA-encoded library targeted towards cysteine protease

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