Michael McPherson; Martin C. Wright; Peter A. Lohse
Synlett, 1999, S1, 978-980
https://doi.org/10.1055/s-1999-3107

Abstract

A convergent strategy for the synthesis of an RNA-peptide conjugate is presented. Regioselective ligation between a 5′-modified RNA harboring a 5′-thioester group and a peptide carrying an N-terminal cysteine afforded an RNA-peptide conjugate under physiological conditions without the need for protecting groups.