Synthesis of Encoded Modified Oligonucleotide Libraries. Part 1 Orthogonal Chemistry.

Paula A. Sacca; Angelo Fontana; Javier M. Montserrat; Adolfo M. Iribarren
Chem. Biodivers., 2004, 1, 595-600
https://doi.org/10.1002/cbdv.200490049

Abstract

The basis for further development of combinatorial libraries of modified oligonucleotides tagged by a codifying sequence is discussed. The chemistry involved in the orthogonal synthesis of both strands and some representative examples of building blocks are presented.

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