Xianfu Fang; Tianyang Zhang; Wei Fang; Gong Zhang; Yangfeng Li; Yizhou Li
Org. Lett. 2023, 25(46), 8326–8331
https://doi.org/10.1021/acs.orglett.3c03404

Abstract

Triazoles are privileged structural motifs that are embedded in a number of molecules with interesting biological activities. In this work, we developed a practical and general synthetic strategy to construct a medicinally important 5-amino-1,2,3-triazole moiety on DNA by coupling DNA-conjugated azides and monosubstituted acetonitriles via azide-acetonitrile “click” reaction. Under mild reaction conditions, this reaction displayed a broad substrate scope. Most substrates gave moderate-to-excellent conversions. Thus, this DNA-compatible reaction could be employed in practical DNA-encoded library (DEL) construction and potentially expand the chemical space of DNA-encoded libraries.