Liqiang Su; Jing Feng; Ting Peng; Jinqiao Wan; Jing Fan; Jin Li; Jonathan O’Connell; David R. Lancia Jr.; G. Joseph Franklin; Guansai Liu
Org. Lett., 2020, 22, 4, 1290-1294
https://doi.org/10.1021/acs.orglett.9b04578

Abstract

2-Aminobenzimidazole cores are among the most common structural components in medicinal chemistry and can be found in many biologically active molecules. Herein, we report a mild protocol for the synthesis of multifunctional 2-aminobenzimidazoles on-DNA with broad substrate scopes. The reaction conditions expand our ability to design and synthesize 2-aminobenzimidazole core-focused DNA-encoded libraries.