Sixiu Liu; Jingjing Qi; Weiwei Lu; Xuan Wang; Xiaojie Lu
Org. Lett., 2021, 23, 3, 908-913
https://doi.org/10.1021/acs.orglett.0c04118

Abstract

Taking advantage of the diversity-oriented synthesis strategy with α,β-unsaturated carbonyl compounds, we have successfully established the DNA-compatible transformations for various heterocyclic scaffolds. The ring-closure reactions for pyrrole, pyrrolidine, pyrazole, pyrazoline, isoxazoline, pyridine, piperidine, cyclohexenone, and 5,8-dihydroimidazo[1,2-a]pyrimidine were elegantly demonstrated in a DNA-compatible format. These efforts paved the way for preparing DNA-encoded libraries with more extensive chemical space.