Cristina Martini; Muhammad Idham Darussalam Mardjan; Andrea Basso
Beilstein J. Org. Chem., 2024, 20, 1839-1879
https://doi.org/10.3762/bjoc.20.162

Abstract

The Groebke–Blackburn–Bienaymé (GBB) three-component reaction, discovered in 1998, is a very efficient strategy to assemble imidazo[1,2-a]-heterocycles starting from amidines, aldehydes and isocyanides. This review aims to exhaustively describe innovative aspects of this reaction achieved during the last five years, and classifies them into five categories: synthetic methods, building blocks, scaffolds, biological activities and physical properties.