Oliver Plettenburg
Isr. J. Chem., 2019, 59, 29-36
https://doi.org/10.1002/ijch.201900007

Abstract

In early times, the drug discovery process was mainly based on profiling of new medications in in vivo systems. In the absence of knowledge on enzymatic structures, biochemical signaling or precise cellular processes, researchers were dependent on knowledgeable readout of phenotypic effects in living animals.