Yasuhiro Uozumi; Aya Tazawa
Synfacts, 2022, 18(04), 0417
https://doi.org/10.1055/s-0041-1737383

Abstract

Transfer Hydrogenolyses and hydrogenations of DNA-conjugated substrates were effected using the micelle-forming surfactant TPGS-750-M. DNA-conjugated N-Cbz and benzyl ethers were deprotected with 10% Pd/C and HCO2NH4 in aqueous TPGS-750-M to give the corresponding amines and alcohols in up to 100% conversion.
Transfer hydrogenations of DNA-conjugated nitro-benzenes, aryl halides, alkenes, alkynes, nitriles, and aldehydes were also preformed under similar conditions to afford the corresponding hydrogenated products in up to 100% conversion.