Paul Edwards
Drug Discov. Today, 2010, 15, 15–16, 690-691
https://doi.org/10.1016/j.drudis.2010.06.013

Abstract

Molecules with biological activity emerge in living systems through cycles of translation, selection, and amplification with mutation. Scientists have adopted features of biological evolution to create DNA, RNA, and protein molecules with tailor-made binding or catalytic properties. The benefits to the discovery of functional molecules by applying translation and selection-based methods has provided the impetus to develop new approaches to addressing translating DNA sequences into structures not necessarily compatible with polymerase enzymes or ribosomal machinery. For example, a ‘DNA display’ method in which resin-bound DNA hybridization directs split-andpool combinatorial synthesis, as well as the use of DNA display to generate libraries of linear peptides and peptoids has been developed