Kenneth J. DiRico; Wenyi Hua; Chang Liu; Joseph W. Tucker; Anokha S. Ratnayake; Mark E. Flanagan; Matthew D. Troutman; Mark C. Noe; Hui Zhang
ACS Med. Chem. Lett., 2020, 11, 6, 1101-1110
https://doi.org/10.1021/acsmedchemlett.0c00066

Abstract

High-throughput experimentation (HTE) has emerged as an important tool in drug discovery, providing a platform for preparing large compound libraries and enabling swift reaction screening over wide-ranging conditions. Recent advances in automated high-density, material-sparing HTE have necessitated the development of rapid analytics with sensitivity and resolution sufficient to identify products and/or assess reaction performance in a timely and data-rich manner. Combination of an ultrathroughput (UT) reader platform with Acoustic Droplet Ejection-Open Port Interface-Mass Spectrometry (ADE-OPI-MS) provides the requisite speed and sensitivity. Herein, we report the application of ADE-OPI-MS to HTE in the areas of parallel medicinal chemistry and reaction screening.